General
Preferred name
priralfinamide
Synonyms
Ralfinamide mesylate ()
Ralfinamide (mesylate) ()
FCE-26742A (mesylate) ()
FCE-26742A ()
RALFINAMIDE ()
NW-1029 ()
PNU-0154339E ()
P&D ID
PD070135
CAS
133865-88-0
202825-45-4
Tags
available
drug candidate
Drug indication
Neuropathic pain
Drug Status
investigational
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents. It displays analgesic effects in animal models of inflammatory and neuropathic pain.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Na+ channel blocker
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
302.14
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.37
TPSA
64.35
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Target
Sodium Channel
Na-channel
CACNA1B
Pathway
Membrane Transporter/Ion Channel
MOA
Sodium Channel blocker
Therapeutic Class
Analgesics
Source data
