General
Preferred name
WYE-687
Synonyms
WYE 687 ()
WYE 687 dihydrochloride ()
WYE-687 (dihydrochloride) ()
P&D ID
PD070070
CAS
1702364-87-1
1062161-90-3
Tags
available
probe
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
148
No orthogonal probes found
Similar probes
79
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
gamma-secretase inhibitor; lowers Abeta40 and Abeta42 levels
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective mTOR inhibitor
(Tocriscreen Plus)
DESCRIPTION
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
7
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
528.26
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
6
Aromatic Ring Count
4
cLogP
3.74
TPSA
110.53
Fraction CSP3
0.39
Chiral centers
0.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target Type
Enzymes
Primary Target
mTOR
MOA
Inhibitor
mTOR inhibitor
Target
PI3K
MTOR
Pathway
PI3K/Akt/mTOR
Source data