General
Preferred name
VU 0357017 hydrochloride
Synonyms
ML071 ()
ML071 hydrochloride ()
CID-25010775 ()
VU0357017 (hydrochloride) ()
VU0357017 Hydrochloride ()
P&D ID
PD070065
CAS
1135242-13-5
1135681-23-0
Tags
available
probe
biased GPCR ligand
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
6
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M1 muscarinic acetylcholine receptor, with an EC50 of 477 nM. VU0357017 hydrochloride is highly selective for M1 and has no activity at M2-M5 up to the highest concentrations tested (30 ¦ÌM). VU0357017 hydrochloride can be used for the research of Alzheimer¡¯s disease and schizophrenia[1][2][3].
PRICE
71
DESCRIPTION
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ?? 172 nM; Pec50: 6.37 ?? 0.15).
DESCRIPTION
To identify small molecule agonists of M1 muscarinic receptor that are cell permeable, exhibit submicromolar potency, and show greater than 10 fold selectivity over other muscarinic family members M2, M3, M4 and M5.
(MLP Probes)
DESCRIPTION
GPR35 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
VU0357017 hydrochloride (ML071 hydrochloride) is highly selective M1 agonists act at an allosteric site to activate the receptor (EC50: 477 ± 172 nM; Pec50: 6.37 ± 0.15).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Axon Medchem Screening Library
BiasDB
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
MLP Probes
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
333.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
1.94
TPSA
70.67
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Antitarget
M2-M5
Target
M1
M1 mAChR
mAChR
M1 PAM
AChR
Primary Target
M1 Receptors
MOA
AChR inhibitor
Modulator
Pathway
Neuroscience
GPCR/G protein
Neuronal Signaling
Source data
