General
Preferred name
NIGERICIN
Synonyms
Sodium Nigericin ()
Nigericin sodium salt ()
Nigericin (sodium salt) ()
NIGERICIN SODIUM ()
P&D ID
PD070059
CAS
28380-24-7
28643-80-3
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 140
DESCRIPTION Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which inhibits Golgi function and suppresses the growth of Gram-positive bacteria.
PRICE 173
DESCRIPTION Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/??-catenin signaling downregulation.
DESCRIPTION Potent and selective TRPV1 antagonist (Tocris Bioactive Compound Library)
Cell lines
3
Organisms
2
Compound Sets
4
CZ-OPENSCREEN Bioactive Library
DrugBank
DB14056
MedChem Express Bioactive Compound Library
HY-100381
HY-127019
Tocris Bioactive Compound Library
4312
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
724.48
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
6
Aromatic Ring Count
0
cLogP
5.71
TPSA
142.37
Fraction CSP3
0.97
Chiral centers
19.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Ionophores
Target
antibiotic
Bacterial
NOD-like Receptor (NLR)
Potassium Channel
Pyroptosis
Wnt
β-catenin
Pathway
Anti-infection
Apoptosis
Immunology/Inflammation
Membrane Transporter/Ion Channel
Stem Cell/Wnt
Source data