General
Preferred name
Dolastatin 10
Synonyms
DOLASTATIN-10 ()
DLS 10 ()
NSC 376128 ()
Dolostatin 10 ()
P&D ID
PD070053
CAS
110417-88-4
Tags
drug candidate
natural product
available
Drug indication
Leukemia
Solid tumour/cancer
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
21
Organisms
1
Compound Sets
7
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
784.49
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
21
Ring Count
3
Aromatic Ring Count
2
cLogP
5.19
TPSA
133.41
Fraction CSP3
0.69
Chiral centers
9.0
Largest ring
6.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
TUBB
ADC Cytotoxin
Microtubule/Tubulin
MOA
tubulin polymerization inhibitor
Pathway
Antibody-drug Conjugate/ADC Related
Cell Cycle/DNA Damage
cytoskeleton
Source data
