General
Preferred name
A-484954
Synonyms
A 484954 ()
P&D ID
PD069844
CAS
142557-61-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC50 of 280 nM.
PRICE 90
DESCRIPTION A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. (BOC Sciences Bioactive Compounds)
DESCRIPTION A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor. (TargetMol Bioactive Compound Library)
DESCRIPTION NAMPT inhibitor; also GLUT1 inhibitor (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
7
AdooQ Bioactive Compound Library
A13447
BOC Sciences Bioactive Compounds
a-484954-cas-142557-61-7-item-118964
Cayman Chemical Bioactives
28279
EU-OPENSCREEN Bioactive Compound Library
EOS100145
MedChem Express Bioactive Compound Library
HY-110096
TargetMol Bioactive Compound Library
TQ0137
Tocris Bioactive Compound Library
4483
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
289.12
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.41
TPSA
126.0
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Autophagy
Microbiology/virology
Neuroscience
Neuronal Signaling
Primary Target
CaM Kinase
MOA
Inhibitor
Target
CaMK
eEF2
Source data