General
Preferred name
GRI 977143
Synonyms
GRI977143 ()
GRI-977143 ()
P&D ID
PD069706
CAS
325850-81-5
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GRI977143 is a specific LPA2 receptor agonist, with an EC50 of 3.3 ¦ÌM [1].
PRICE 108
DESCRIPTION GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 ??M). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation.
DESCRIPTION GRI 977143 is a selective and non-lipid agonist of lysophosphatidic acid 2 (LPA2) receptor (EC50 = 3.3 μM) exhibiting no activity for other LPA GPCRs at concentrations up to 10 μM. GRI 977143 inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. It also activates ERK1/2 survival pathway. (BOC Sciences Bioactive Compounds)
DESCRIPTION GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragmentation. (TargetMol Bioactive Compound Library)
DESCRIPTION Positive allosteric modulator of mGlu1 and mGlu5 receptors (Tocris Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
gri-977143-cas-325850-81-5-item-119185
Cayman Chemical Bioactives
21900
MedChem Express Bioactive Compound Library
HY-100676
ReFrame library
TargetMol Bioactive Compound Library
T22812
Tocris Bioactive Compound Library
4779
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
391.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.32
TPSA
74.68
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
LPA2
Caspase
LPL Receptor
Primary Target
Lysophosphatidic Acid Receptors
MOA
Agonist
Pathway
GPCR/G protein
Apoptosis
Source data