General
Preferred name
(R)-CE3F4
Synonyms
P&D ID
PD069696
CAS
1593478-56-8
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 ¦ÌM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 ¦ÌM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1].
DESCRIPTION
(R)-CE3F4 is an Epac inhibitor (IC50 = 4.2 and 44 μM for Epac1 and Epac2(B), respectively), suppressing the activation of Epac by cAMP.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
348.91
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
3.65
TPSA
20.31
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
EPAC
MOA
Inhibitor
Target
EPAC1 inhibitor
Ras
Pathway
GPCR/G protein
MAPK/ERK Pathway
Source data
