General
Preferred name
DY 268
Synonyms
DY-268 ()
DY268 ()
P&D ID
PD069418
CAS
1609564-75-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION DY268 is a farnesoid X receptor (FXR) antagonist (IC50=7.5 nM). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM. DY268 can be used in the study of drug-induced liver injury (DILI)[1][2].
PRICE 138
DESCRIPTION DY-268, a pyrazol carboamide derivative, has been found to be a FXR antagonist that could be significant in studies of the biological activities of FXR. IC50: 7.5 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM). (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective PPARdelta agonist (Tocris Bioactive Compound Library)
Compound Sets
10
Axon Medchem Screening Library
2561
BOC Sciences Bioactive Compounds
dy-268-cas-1609564-75-1-item-475894
Cayman Chemical Bioactives
29475
EUbOPEN Chemogenomics Library
EUB0001174
Guide to Pharmacology
14078
Mcule NIBR MoA Box Subset
MCULE-3839361365
MedChem Express Bioactive Compound Library
HY-110267
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T31587
Tocris Bioactive Compound Library
5656
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
560.21
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
4
cLogP
4.5
TPSA
102.76
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.34
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
FXR
FXR antagonist
Primary Target
LXR-like Receptors
MOA
Antagonist
NR1H4 gene inhibitor
Member status
member
Pathway
Metabolic Enzyme/Protease
Metabolism
Solubility
DMSO: 100 mM
Recommended Cell Concentration
1 uM
Source data