General
Preferred name
ENSACULIN
Synonyms
ANSECULIN HYDROCHLORIDE ()
Anseculin ()
Ensaculin hydrochloride ()
Ensaculina ()
Ensaculine ()
P&D ID
PD068161
CAS
155773-59-4
Tags
available
drug candidate
Drug indication
Parkinson disease
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
441
DESCRIPTION
Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugMAP
DrugMatrix
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
452.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
3
cLogP
4.02
TPSA
64.38
Fraction CSP3
0.42
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
