General
Preferred name
UK-74505
Synonyms
MODIPAFANT ()
UK 74505 ()
UK74505 ()
Modipafant racemate ()
(Rac)-Modipafant ()
P&D ID
PD066116
CAS
122956-68-7
Tags
available
drug candidate
Drug indication
Sepsis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION (Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection[1][2][3].
PRICE 851
DESCRIPTION (Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
5
DrugMAP
DMAD1S5
DrugMatrix
MedChem Express Bioactive Compound Library
HY-108908
ReFrame library
TargetMol Bioactive Compound Library
T28081
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
604.2
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
6
Aromatic Ring Count
5
cLogP
6.35
TPSA
111.03
Fraction CSP3
0.15
Chiral centers
1.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PAFR
Dengue virus
Flavivirus
Pathway
GPCR/G protein
Anti-infection
Source data