General
Preferred name
JATRORRHIZINE
Synonyms
Yatrorizine ()
neprotin ()
Yatrorhizine chloride ()
Neprotine chloride ()
Jatrorrhizine (chloride) ()
Jatrorrhizine (hydroxide) ()
neprotin, Yatrorizine ()
Neprotine chloride, Yatrorhizine chloride ()
JATRORRHIZINE CHLORIDE ()
Jatrorrhizine hydrochloride ()
P&D ID
PD065121
CAS
3621-38-3
6681-15-8
483-43-2
960383-96-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
59
PRICE
29
DESCRIPTION
Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities[1]. Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
PRICE
40
DESCRIPTION
Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).
DESCRIPTION
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
(TargetMol Bioactive Compound Library)
DESCRIPTION
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
6
Cayman Chemical Bioactives
DrugMAP
Other bioactive compounds
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
338.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.08
TPSA
51.8
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
AChE
Bacterial
MAO-A
MAO-B
OCT
PMAT
Cholinesterase (ChE)
AChR
MOA
MAO inhibitor
Pathway
GPCR/G protein
Metabolism
Microbiology/virology
Neuroscience
Membrane Transporter/Ion Channel
Anti-infection
Neuronal Signaling
Source data
