General
Preferred name
VELUTIN
Synonyms
P&D ID
PD065071
CAS
25739-41-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Velutin is an aglycone extracted from Flammulina velutipes, with inhibitory activity against melanin biosynthesis. Velutin reduces osteoclast differentiation and down-regulates HIF-1¦Á through the NF-¦ÊB pathway[1][2].
PRICE 381
DESCRIPTION Velutin shows the strongest inhibitory effect in NF-??B activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-??B as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation. Velutin has anti-inflammatory property. Velutin exhibits the greatest potency among all flavones which reduce TNF-?? and IL-6 production.
Compound Sets
1
MedChem Express Bioactive Compound Library
HY-N1098
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
314.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
2.89
TPSA
89.13
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
MOA
NF-¦ÊB inhibitor
Pathway
NF-¦ªb
Metabolic Enzyme/Protease
Target
NF-¦ÊB
HIF/HIF Prolyl-Hydroxylase
Source data