General
Preferred name
SILVESTROL
Synonyms
CHEMBL555196 ()
(-)-Silvestrol ()
P&D ID
PD064274
CAS
697235-38-4
Tags
available
drug candidate
natural product
probe
Drug indication
Cancer
Solid tumour/cancer
Middle East Respiratory Syndrome (MERS)
Probe info
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
0
Compound Sets
4
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
654.23
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
4
Rotatable Bonds
10
Ring Count
6
Aromatic Ring Count
3
cLogP
1.57
TPSA
171.83
Fraction CSP3
0.44
Chiral centers
9.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Eukaryotic initiation factor 4A-I
Eukaryotic Initiation Factor (eIF)
Therapeutic Class
Antiviral Agents
Pathway
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Source data
