General
Preferred name
ISOXANTHOHUMOL
Synonyms
P&D ID
PD064016
CAS
70872-29-6
521-48-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Isoxanthohumol is a prenylflavonoid from hops and beer. Isoxanthohumol exhibits an antiproliferative activity against several human cancer cell lines. Isoxanthohumol inhibits the development of lung metastatic foci in tumor-challenged animals. Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV)[1][2].
PRICE 122
DESCRIPTION Isoxanthohumol is a prenylated flavonoid derived from hops and beer with antiproliferative activity against several human cancer cell lines.Isoxanthohumol inhibits the metastasis or invasion of lung metastases of tumor cells.Isoxanthohumol has antiviral activity against herpesviruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). (TargetMol Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
3
Cayman Chemical Bioactives
23233
MedChem Express Bioactive Compound Library
HY-N2584A
TargetMol Bioactive Compound Library
T75643
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
354.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.32
TPSA
75.99
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology/virology
Microbiology&virology
Anti-infection
cytoskeleton
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
MOA
HSV
BVDV
Target
HSV-1
HSV-2
Apoptosis
Autophagy
CMV
Fungal
Integrin
Reactive Oxygen Species (ROS)
S100 Protein
Source data