General
Preferred name
COIXOL
Synonyms
6-methoxybenzoxazolone ()
6-MBOA ()
6-Methoxy-2-benzoxazolinone ()
MBOA ()
6-methoxybenzoxazolone, MBOA ()
P&D ID
PD063927
CAS
532-91-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Coixol (6-Methoxy-2-benzoxazolinone; 6-MBOA) is a potent and orally active anti-inflammatory agent. Coixol decreases the iNOS protein expression. Coixol inhibits the production of TNF-¦Á, IL-6, and IL-1¦Â. Coixol improves glucose tolerance and plasma insulin. Coixol decreases the blood glucose level[1][2][3].
PRICE 29
DESCRIPTION 6-Methoxy-2-benzoxazolinone is an alkaloid isolated from the seed of Coix lacryma-jobi L. var. meyuan (Romen.) Stapf. It acts as a central muscle relaxant with an anti-convulsant effect. (BOC Sciences Bioactive Compounds)
DESCRIPTION 1. Coixol (MBOA) acts as a central muscle relaxant with an anti-convulsant effect. 2. Coixol interacts with the pituitary to stimulate reproduction in voles. 3. Coixol has the ability to interact with FSH to stimulate follicular development and increase ovulation. 4. Coixol can regulate gene expression, production and secretion of mucin, by directly acting on airway epithelial cells. (TargetMol Bioactive Compound Library)
Compound Sets
4
BOC Sciences Bioactive Compounds
6-methoxy-2-benzoxazolinone-cas-532-91-2-354006
MedChem Express Bioactive Compound Library
HY-N0936
Selleckchem Bioactive Compound Library
coixol
TargetMol Bioactive Compound Library
T2S2108
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
165.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.13
TPSA
55.23
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Bacterial
Pathway
Microbiology/virology
Solubility
Soluble in Acetone, Dichloromethane, DMSO, Methanol, Tetrahydrofuran
Source data