General
Preferred name
NUCIFERINE
Synonyms
(-)-Nuciferine ()
VLT 049 ()
Sanjoinine E ()
Sanjoinine E, (-)-Nuciferine, VLT 049| ()
Sanjoinine E(-)-Nuciferine ()
Sanjoinine E, (-)-Nuciferine, VLT 049 ()
P&D ID
PD063857
CAS
475-83-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 ¦ÌM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 ¦ÌM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 ¦ÌM) and D4 (EC50=2 ¦ÌM) receptor.
PRICE 41
DESCRIPTION Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. (TargetMol Bioactive Compound Library)
Compound Sets
4
Cayman Chemical Bioactives
34221
33839
MedChem Express Bioactive Compound Library
HY-N0049
Selleckchem Bioactive Compound Library
nuciferine
TargetMol Bioactive Compound Library
T3369
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
295.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
3.46
TPSA
21.7
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT2A
5-HT2B
5-HT2C
5-HT7
D5 receptor
dopamine
Dopamine Receptor
Parasite
5-HT Receptor,5-HT Receptor,Dopamine Receptor
Pathway
Anti-infection
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data