General
Preferred name
PF-06650833
Synonyms
PF06650833 ()
PF 06650833 ()
zimlovisertib ()
Zimlovisertib (PF-06650833) ()
P&D ID
PD063743
CAS
1817626-54-2
Tags
available
probe
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Rheumatoid arthritis
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas[1][2].
PRICE 86
DESCRIPTION PF-06650833 is a small molecule, reversible, potent and selective IRAK4 inhibitor identified as a clinical lead . Its pharmacokinetic profile suggests it will be orally bioavailable. Structurally it is an analogue of . The chemical structure for the INN zimlovisertib is identical to the structure of PF-06650833. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION Zimlovisertib is a potent and selective inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 nM. (Enamine Bioactive Compounds)
DESCRIPTION Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay). (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective irreversible FAAH inhibitor (Tocris Bioactive Compound Library)
Compound Sets
17
Cayman Chemical Bioactives
28397
ChEMBL Drugs
CHEMBL4081711
Chemical Probes.org
zimlovisertib
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB15143
Enamine Bioactive Compounds
EBC-412094
EU-OPENSCREEN Bioactive Compound Library
EOS100210
EUbOPEN Chemogenomics Library
EUB0000639
Guide to Pharmacology
9667
High-quality chemical probes
PD063743
MedChem Express Bioactive Compound Library
HY-19836
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
pf-06650833
TargetMol Bioactive Compound Library
TQ0167
Tocris Bioactive Compound Library
6373
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
361.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
1.58
TPSA
103.54
Fraction CSP3
0.39
Chiral centers
3.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
IRAK
IRAK-4
IRAK4
MOA
Inhibitor
kinase inhibitor
Pathway
Immunology/Inflammation
NF-κB
Target class
Kinase
Target subclass
TKL
Control
CANSAR1682746
Recommended Cell Concentration
100 nM
Source data