General
Preferred name
FX1
Synonyms
FX 1 ()
P&D ID
PD063732
CAS
1426138-42-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 ¦ÌM.
PRICE 42
DESCRIPTION FX1 is an effective and selective BCL6 inhibitor (IC50: 35 ??M).
DESCRIPTION FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactivate BCL6 target genes and mimick the phenotype of mice engineered to express BCL6 with corepressor binding site mutations. FX1 also inhibits ABC-DLBCL cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION FX1 is an effective and selective BCL6 inhibitor (IC50: 35 μM). (TargetMol Bioactive Compound Library)
DESCRIPTION Purine nuceloside analog; inhibits DNA synthesis (Tocris Bioactive Compound Library)
Cell lines
14
Organisms
0
Compound Sets
6
BOC Sciences Bioactive Compounds
fx1-cas-1426138-42-2-item-8135
Cayman Chemical Bioactives
23908
MedChem Express Bioactive Compound Library
HY-102027
Selleckchem Bioactive Compound Library
fx1
TargetMol Bioactive Compound Library
T4089
Tocris Bioactive Compound Library
6323
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
367.97
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
2.34
TPSA
86.71
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
1
ene_rhod_A(235)
[#7]-1-[#6](=[#16])-[#16]-[#6](=[#6])-[#6]-1=[#8]
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Bcl-2 Family
BCL-6
Apoptosis related,Bcl-6
MOA
Inhibitor
Solubility
DMSO Solubility: 73 mg/mL (197.92 mM)
Source data