General
Preferred name
Corydaline
Synonyms
Corydalin(+)-Corydaline ()
(+)-Corydaline ()
Corydalin ()
P&D ID
PD063730
CAS
518-69-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 ¦ÌM. Corydaline is a ¦Ì-opioid receptor (Ki of 1.23 ¦ÌM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 ¦ÌM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities[1][2][3].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
3
Cayman Chemical Bioactives
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
369.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.94
TPSA
40.16
Fraction CSP3
0.45
Chiral centers
2.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
P450
Target
Cholinesterase (ChE)
Enterovirus
Opioid Receptor
AChR
Pathway
Anti-infection
GPCR/G protein
Neuronal Signaling
Source data
