General
Preferred name
UK-371804
Synonyms
UK371804 ()
UK-371804 Dihydrate ()
UK-371804 HCl ()
UK 371804 ()
P&D ID
PD063684
CAS
256477-09-5
256476-36-5
2445792-56-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 10 nM.
PRICE
152
DESCRIPTION
UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.
(TargetMol Bioactive Compound Library)
DESCRIPTION
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor. Study in vitro showed that it inhibited exogenous uPA in human chronic wound fluid (IC50=0.89 mM); In a porcine acute excisional wound model, it penetrated into pig wounds and suppressed exogenous uPA activity. UK-371804 is promisingly to be used for the treatment of chronic dermal ulcers.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
UK-371804 is an urokinase-type plasminogen activator (uPA) inhibitor.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
385.06
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
1.34
TPSA
158.26
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PAI-1
uPA
Serine Protease
Pathway
Metabolic Enzyme/Protease
Metabolism
Proteases/Proteasome
Solubility
DMSO Solubility: 30 mg/mL warmed (71.04 mM)
Source data
