General
Preferred name
SCUTELLARIN
Synonyms
Scutellarein-7-glucuronide ()
Breviscapin ()
Breviscapine ()
Breviscapinun ()
Scutellarin B ()
Breviscapine, Breviscapin, Scutellarein-7-glucuronide ()
P&D ID
PD063606
CAS
1329-06-2
116122-36-2
27740-01-8
Tags
available
drug candidate
natural product
Drug indication
Cerebrovascular ischaemia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-¦ÊB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 ¦ÌM, 253 ¦ÌM and 136 ¦ÌM, respectively.
PRICE 37
DESCRIPTION Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-??B signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells.
DESCRIPTION Scutellarin is a bioactive plant-derived flavinoid compound that has been isolated from plants including Scoparia dulcis (sweet broom), Sempervivum ruthenicum (houseleek), the daisy-like plant Erigeron breviscapus and Scutellaria species (skullcaps). It has been used as a traditional herbal remedy, and has more recently been investigated for actions that support anti-cancer potential . Integrated network pharmacology predictive analysis followed by experimental validation suggests that the c-Jun N-terminal kinases (JNK) pathway is important for scutellarin's bioactivity in acute myeloid leukemia (AML) models . (GtoPdb)
DESCRIPTION Scutellarin (Scutellarein-7-glucuronide), an active flavone isolated from Scutellaria baicalensis, can inhibit RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts, and down-regulate the STAT3/Girdin/Akt signaling in HCC cells. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
0
Compound Sets
7
AdooQ Bioactive Compound Library
A12117
Cayman Chemical Bioactives
27461
DrugMAP
DMJT1E5
Guide to Pharmacology
13075
MedChem Express Bioactive Compound Library
HY-N0751
Selleckchem Bioactive Compound Library
scutellarin
TargetMol Bioactive Compound Library
T2789
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
462.08
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
7
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
-0.15
TPSA
207.35
Fraction CSP3
0.24
Chiral centers
5.0
Largest ring
6.0
QED
0.25
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Akt
HIV
STAT
Akt,NF-¦ÊB,STAT
MOA
AKT
Pathway
Cytoskeletal Signaling
JAK/STAT Signaling
Microbiology/virology
PI3K/Akt/mTOR signaling
Proteases/Proteasome
Stem Cells
Anti-infection
PI3K/Akt/mTOR
Stem Cell/Wnt
Source data