General
Preferred name
Astragaloside II
Synonyms
Astrasieversianin VIII ()
P&D ID
PD063539
CAS
84676-89-1
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1¦Â), HIF-¦Á, p-p65, p-I¦ÊB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis[1][2][3][4][5].
PRICE 165
DESCRIPTION Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, proliferation, and mineralization, through the bone morphogenetic protein-2/MAPK and Smad1/5/8 pathways. (TargetMol Bioactive Compound Library)
Compound Sets
3
Cayman Chemical Bioactives
40139
MedChem Express Bioactive Compound Library
HY-N0433
TargetMol Bioactive Compound Library
T3924
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
826.47
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
8
Rotatable Bonds
8
Ring Count
8
Aromatic Ring Count
0
cLogP
1.29
TPSA
234.29
Fraction CSP3
0.98
Chiral centers
21.0
Largest ring
6.0
QED
0.13
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Stem Cells
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-¦ÊB
Target
Autophagy
HIF/HIF Prolyl-Hydroxylase
Interleukin Related
NF-κB
SOD
Smad1
Smad5
Smad8
Source data