General
Preferred name
AF38469
Synonyms
AF-38469 ()
P&D ID
PD063382
CAS
1531634-31-7
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
PRICE 233
DESCRIPTION AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
35530
Drug Repurposing Hub
Mcule NIBR MoA Box Subset
MCULE-9539265162
MedChem Express Bioactive Compound Library
HY-12802
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
af38469
TargetMol Bioactive Compound Library
TQ0086
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
324.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
3.36
TPSA
79.29
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Neurotensin Receptor
Sortilin
SORT1
Member status
member
MOA
sortilin inhibitor (SORT1)
sortilin inhibitor
Pathway
GPCR/G protein
Neuronal Signaling
Source data