General
Preferred name
CEFTIOFUR
Synonyms
Naxcel ()
Sodium ceftiofur ()
CEFTIOFUR HYDROCHLORIDE ()
Ceftiofur (hydrochloride) ()
CEFTIOFUR SODIUM ()
Ceftiofur crystalline free acid ()
U-64279A ()
Ceftiofur monohydrochloride ()
Ceftiofur HCl ()
NSC-759845 ()
P&D ID
PD063104
CAS
103980-44-5
80370-57-6
104010-37-9
Tags
available
drug
drug candidate
Approved by
FDA
Drug indication
Bacterial infection
Drug Status
vet_approved
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ceftiofur is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur also inhibits the activation of NF-¦ÊB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-¦Á, IL-1¦Â, and IL-6[1][2][3].
DESCRIPTION
Ceftiofur hydrochloride is a cell wall synthesis inhibitor that targets bacterial penicillin-binding proteins (PBPs) and has anti-inflammatory effects in endotoxemia. Ceftiofur hydrochloride exerts bactericidal effects by inhibiting the synthesis of bacterial cell wall peptidoglycan, leading to bacterial cell lysis. Ceftiofur hydrochloride also inhibits the activation of NF-¦ÊB and MAPKs, thereby reducing the secretion of pro-inflammatory cytokines such as TNF-¦Á, IL-1¦Â, and IL-6[1][2][3].
PRICE
29
DESCRIPTION
Ceftiofur sodium (Naxcel), an antibiotic of the cephalosporin type (third generation), is used as veterinary medicine.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
523.03
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
4
Aromatic Ring Count
2
cLogP
0.98
TPSA
177.42
Fraction CSP3
0.26
Chiral centers
2.0
Largest ring
6.0
QED
0.26
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antibacterial
antibiotic
Bacterial
Interleukin Related
NF-κB
p38 MAPK
TNF Receptor
Indication
pneumonia, respiratory tract infections
MOA
bacterial cell wall synthesis inhibitor
Pathway
Microbiology/virology
Anti-infection
Apoptosis
Immunology/Inflammation
MAPK/ERK Pathway
NF-¦ÊB
Source data
