General
Preferred name
IdB-1056
Synonyms
DELPHINIDIN ()
Deplhinidin ()
Delphinidin (chloride) ()
DELPHINIDIN CHLORIDE ()
P&D ID
PD062974
CAS
528-53-0
13270-61-6
8012-95-1
Tags
available
drug candidate
nuisance
Drug indication
Cardiovascular disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 90
DESCRIPTION Delphinidin chloride, a natural plant pigment found in berries and red wine, is a precursor of certain anthocyanins. Delphinidin chloride induces the release of nitric oxide from the vascular endothelium, resulting in vascular relaxation. At the dose of 1-40 ??M, epithelial growth factor receptor signaling and estrogen receptor ?? expression were inhibited, which was associated with apoptosis and autophagy. Delphinidin chloride regulates JAK/STAT3 and MAPKinase signaling. Delphinidin also inhibited the histone acetyltransferase activity of p300/CBP (IC50 was about 30 ??M).
Cell lines
1
Organisms
0
Compound Sets
7
Cayman Chemical Bioactives
11012
Drug Repurposing Hub
DrugMAP
DMS2WIN
DrugMatrix
MedChem Express Bioactive Compound Library
HY-N2409
Nuisance compounds in cellular assays
ReFrame library
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
303.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
6
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.61
TPSA
132.68
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
2
Aggregator (Nuisance compounds)
Aggregators
Aggregation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target
GLO1
Apoptosis
EGFR
JAK
STAT
MOA
membrane permeability inhibitor
Pathway
Epigenetics
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
Source data