General
Preferred name
ETC-159
Synonyms
ETC159 ()
ETC-1922159 ()
ETC 159 ()
Etc-1922159 ()
P&D ID
PD062918
CAS
1638250-96-0
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Neoplasm
Drug Status
investigational
Max Phase
1.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. ETC-159 inhibits ¦Â-catenin reporter activity with an IC50 of 2.9 nM.
PRICE 57
DESCRIPTION ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits ??-catenin reporter activity with an IC50 of 2.9 nM.
DESCRIPTION ETC-1922159 (ETC-159) is an orally bioavailable, clinical stage porcupine inhibitor . It is being developed for oncology potential. (GtoPdb)
DESCRIPTION ETC-159, also known as ETC-1922159, is a potent, selective and orally available PORCN inhibitor. ETC-159 blocks the secretion and activity of all Wnts. (BOC Sciences Bioactive Compounds)
DESCRIPTION ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor that inhibits β-catenin reporter activity with an IC50 of 2.9 nM. (TargetMol Bioactive Compound Library)
Compound Sets
12
AdooQ Bioactive Compound Library
A15840
BOC Sciences Bioactive Compounds
etc-159-cas-1638250-96-0-item-470889
Cayman Chemical Bioactives
24104
ChEMBL Drugs
CHEMBL3633802
Drug Repurposing Hub
DrugMAP
DMY0HU6
EU-OPENSCREEN Bioactive Compound Library
EOS100167
Guide to Pharmacology
11168
MedChem Express Bioactive Compound Library
HY-18988
ReFrame library
Selleckchem Bioactive Compound Library
etc-159
TargetMol Bioactive Compound Library
T4043
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
391.14
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
4
cLogP
0.53
TPSA
116.7
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PORCN
Wnt
β-catenin
Porcupine
MOA
beta catenin inhibitor, porcupine inhibitor
Pathway
Cytoskeletal Signaling
Stem Cells
Stem Cell/Wnt
Solubility
Soluble in DMSO, not in water
Source data