General
Preferred name
MOFEGILINE
Synonyms
MOFEGILINE HYDROCHLORIDE ()
Mofegiline (hydrochloride) ()
MDL72974A ()
Mofegiline hcl ()
MDL 72,974A ()
MDL-72974A ()
Mofegilina ()
P&D ID
PD062489
CAS
120635-25-8
119386-96-8
Tags
available
drug candidate
Drug indication
Cognitive impairment
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of MAO-B, with marked selectivity on the MAO-B over MAO-A with IC50s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO)[1][2][3].
DESCRIPTION Mofegiline was originally identified as a monoamine oxidase B inhibitor . Subsequently it has also been identified as an allylamine type irreversible, mechanism-based inhibitor of SSAO/VAP-1 enzyme activity . It has antiinflammatory effects in vitro and in vivo. However mofegiline lacks the selectivity exhibited by more recently developed inhibitors such as . (GtoPdb)
Compound Sets
8
Cayman Chemical Bioactives
35010
ChEMBL Drugs
CHEMBL2106694
CHEMBL489079
Drug Repurposing Hub
DrugMAP
DMJ59A4
EU-OPENSCREEN Bioactive Compound Library
EOS100269
Guide to Pharmacology
9754
MedChem Express Bioactive Compound Library
HY-16677A
ReFrame library
External IDs
32
Properties
(calculated by RDKit )
Molecular Weight
197.1
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
2.57
TPSA
26.02
Fraction CSP3
0.27
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MAOA, MAOB
Monoamine Oxidase
MOA
monoamine oxidase inhibitor
Pathway
Neuronal Signaling
Source data