General
Preferred name
PALMATINE
Synonyms
PALMATINE CHLORIDE ()
CALYSTIGINE ()
Berbericinine ()
Burasaine ()
Palmatine (hydroxide) ()
Palmatine (chloride) ()
Berbericinine, Burasaine ()
PALMITINE ()
P&D ID
PD062349
CAS
10605-02-4
131-04-4
3486-67-7
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Palmatine chloride is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 ¦ÌM and 157¦ÌM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine chloride can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 ¦ÌM. Palmatine chloride shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].
PRICE
29
DESCRIPTION
Palmatine hydroxide is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor with IC50s of 3 ¦ÌM and 157¦ÌM against HEK 293-hIDO-1 and rhIDO-1, respectively. Palmatine hydroxide can also inhibit West Nile virus (WNV) NS2B-NS3 protease in an uncompetitive manner with an IC50 of 96 ¦ÌM. Palmatine hydroxide shows anti-cancer, anti-oxidation, anti-inflammatory, neuroprotection, antibacterial, anti-viral activities[1][2][3][4][5].
DESCRIPTION
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
(TargetMol Bioactive Compound Library)
DESCRIPTION
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
10
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
57
Molecular Weight
352.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.38
TPSA
40.8
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChE
BChE
Indoleamine 2,3-Dioxygenase (IDO)
CYP3A4
Apoptosis
Aurora Kinase
Bacterial
mAChR
Parasite
Virus Protease
Calcium Channel
AChR
MOA
dopamine synthesis inhibitor
Pathway
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Metabolism
Neuroscience
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
GPCR/G protein
Metabolic Enzyme/Protease
Neuronal Signaling
Source data
