General
Preferred name
QUIFLAPON
Synonyms
MK-591 ()
MK-0591 ()
L-686708 ()
P&D ID
PD062139
CAS
136668-42-3
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC50 of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC50 values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis[1][2].
PRICE 74
DESCRIPTION Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells. (BOC Sciences Bioactive Compounds)
DESCRIPTION Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively). (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
mk-0591-cas-136668-42-3-item-84-425451
Cayman Chemical Bioactives
37322
ChEMBL Drugs
CHEMBL16596
Drug Repurposing Hub
DrugMatrix
MedChem Express Bioactive Compound Library
HY-10037
ReFrame library
TargetMol Bioactive Compound Library
T16087
ZINC Tool Compounds
ZINC000001914818
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
586.21
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
5
cLogP
9.01
TPSA
64.35
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.17
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
FLAP
ALOX5, ALOX5AP
MOA
leukotriene synthesis inhibitor
Pathway
Immunology/Inflammation
Source data