General
Preferred name
RACTOPAMINE
Synonyms
RACTOPAMINE HYDROCHLORIDE ()
4-(1-hydroxy-2-(4-(4-hydroxyphenyl)butan-2-ylamino)ethyl)phenol ()
Butopamine ()
Ractopamine HCl ()
LYO31537 ()
EL737 ()
LYO-31537 ()
NSC-759638 ()
EL-737 ()
Ractopamine (hydrochloride) ()
Ractopamine-d3 (hydrochloride) ()
P&D ID
PD062136
CAS
90274-24-1
97825-25-7
1219794-72-5
Tags
drug candidate
natural product
drug
available
Drug Status
approved
vet_approved
Approved by
FDA
Drug indication
Growth Stimulant (veterinary)
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ractopamine exhibits agonist activity at the trace amine receptor 1 (TA1) and β-adrenoceptors .
In some countries ractopamine is used as a feed additive in commercial livestock husbandry to increase lean meat mass. This use is banned in the EU and many other countries, but is permitted in countries including the US, Canada, Mexico, Japan and South Korea. Ractopamine's effect on human physiology has not been fully characterised, so the safety of consuming trace ractopamine in meat from treated animals remains controversial.
Commercially used ractopamine is administered as the hydrochloride salt and is a racemic mixture of all 4 possible stereoenantiomers. We show the structure without specified stereochemistry to represent the mixture. (GtoPdb)
In some countries ractopamine is used as a feed additive in commercial livestock husbandry to increase lean meat mass. This use is banned in the EU and many other countries, but is permitted in countries including the US, Canada, Mexico, Japan and South Korea. Ractopamine's effect on human physiology has not been fully characterised, so the safety of consuming trace ractopamine in meat from treated animals remains controversial.
Commercially used ractopamine is administered as the hydrochloride salt and is a racemic mixture of all 4 possible stereoenantiomers. We show the structure without specified stereochemistry to represent the mixture. (GtoPdb)
DESCRIPTION
Ractopamine hydrochloride, a phenethanolamine with beta-adrenergic agonist properties, has the effects of increasing muscle mass and decreasing body fat in rodents and lifestock.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugMatrix
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
301.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.74
TPSA
72.72
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
