General
Preferred name
TECASTEMIZOLE
Synonyms
Norastemizole ()
R-43512 ()
R43512 ()
R 43512 ()
T 1348 ()
Norastemizole (trivial name) ()
Tecastemizol ()
P&D ID
PD062018
CAS
75970-99-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tecastemizole (Norastemizole), a major metabolite of Astemizole, is a potent and selective H1 receptor antagonist. Tecastemizole shows anti-inflammatory activities[1].
PRICE 144
DESCRIPTION Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
9
Cayman Chemical Bioactives
41828
ChEMBL Drugs
CHEMBL61301
Drug Repurposing Hub
DrugBank
DB06457
DrugMAP
DMXF0NS
DrugMatrix
MedChem Express Bioactive Compound Library
HY-105014
ReFrame library
TargetMol Bioactive Compound Library
T26253
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.39
TPSA
41.88
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Neuronal Signaling
Target
KCNH2
Histamine Receptor
H1 receptor
MOA
Histamine Receptor antagonist
Source data