General
Preferred name
Telacebec
Synonyms
IAP6 ()
Q203 ()
Q-203 ()
Q203 from Novartis/NITD ()
Telacebec (Q203) ()
P&D ID
PD061445
CAS
1334719-95-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
COVID-19
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Telacebec (Q203) is a midazopyridine amide compound. Telacebec is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2.7 nM in culture broth medium.
PRICE
151
DESCRIPTION
Telacebec is a first-in-class imidazopyridine amide that inhibits the mycobacterial cytochrome bc1 complex . It is being clinically evaluated as a treatment for tuberculosis (TB).
Telacebec was one of the compounds with activity against Mycobacterium tuberculosis included in the Medicines for Malaria Venture (MMV) Pathogen Box (see MMVOpen for futher details). (GtoPdb)
Telacebec was one of the compounds with activity against Mycobacterium tuberculosis included in the Medicines for Malaria Venture (MMV) Pathogen Box (see MMVOpen for futher details). (GtoPdb)
DESCRIPTION
Q203 is active against Mycobacterium tuberculosis H37Rv with an MIC50 of 2 nM in culture broth medium.
(Enamine Bioactive Compounds)
DESCRIPTION
Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Pathogen Box
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
556.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
4
cLogP
6.76
TPSA
58.87
Fraction CSP3
0.31
Chiral centers
0.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Disease
TUBERCULOSIS
Target
antibiotic
Bacterial
tuberculosis
MOA
Antibiotic
ATP synthase inhibitor
Pathway
Microbiology/virology
Anti-infection
Source data
