General
Preferred name
Urolithin A
Synonyms
3,8-Dihydroxy Urolithin ()
2',7-Dihydroxy-3,4-benzocoumarin ()
P&D ID
PD061164
CAS
1143-70-0
Tags
available
drug candidate
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].
PRICE 35
DESCRIPTION Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. (Enamine Bioactive Compounds)
DESCRIPTION Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (Tocris Bioactive Compound Library)
Compound Sets
10
AdooQ Bioactive Compound Library
A20426
Cayman Chemical Bioactives
22607
Drug Repurposing Hub
DrugBank
DB15464
Enamine Bioactive Compounds
EBC-252133
MedChem Express Bioactive Compound Library
HY-100599
ReFrame library
Selleckchem Bioactive Compound Library
urolithin-a
TargetMol Bioactive Compound Library
T7174
Tocris Bioactive Compound Library
6762
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
228.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
3
cLogP
2.36
TPSA
70.67
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Cell Cycle/DNA Damage
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Target
Apoptosis
Autophagy
DNA synthesis
DNA/RNA Synthesis
Drug Metabolite
Endogenous Metabolite
Reactive Oxygen Species
Mitophagy
Reactive Oxygen Species (ROS)
Primary Target
Akt (Protein Kinase B)
MOA
Antioxidant
Source data