General
Preferred name
Abafungin
Synonyms
Bay w 6341 ()
UNII-11DI31LWXF ()
BAY-W-6341 ()
Abafungina ()
BAY-W-6341- ()
Abafungine ()
P&D ID
PD061030
CAS
15118-67-9
129639-79-8
Tags
available
drug candidate
Drug indication
Fungal infection
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Abafungin, a antifungal agent, inhibitis the transmethylation at the C-24 position of the sterol side chain, catalyzed by the enzyme sterol-C-24-methyltransferase.
PRICE 51
DESCRIPTION Abafungin is a broad-spectrum antifungal agent with a novel mechanism of action originated by York Pharma. In Aug 2009, Phase-III for Dermatomycoses in Japan and Europe was discontinued. At the same time, preclinical for Onychomycosis in United Kingdom was discontinued. (BOC Sciences Bioactive Compounds)
DESCRIPTION Abafungin (Bay w 6341) is an antifungal agent with a broad-spectrum. (TargetMol Bioactive Compound Library)
Compound Sets
10
BOC Sciences Bioactive Compounds
abafungin-cas-129639-79-8-item-56865
Cayman Chemical Bioactives
35465
ChEMBL Drugs
CHEMBL3989547
Drug Repurposing Hub
DrugBank
DB06395
DrugMAP
DM09GSW
MedChem Express Bioactive Compound Library
HY-119847
Pandemic Response Box
ReFrame library
TargetMol Bioactive Compound Library
T21448
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
378.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
4.79
TPSA
58.54
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Fungal
MOA
sterol methyltransferase inhibitor
Pathway
Anti-infection
Solubility
Soluble in DMSO
Source data