General
Preferred name
SODIUM HYDROXIDE
Synonyms
E-524 ()
Tosoh pearl ()
Sodium hydroxide solutions ()
NSC-135799 ()
Aetznatron ()
Stamperprep ()
Promoter 3308b ()
INS-524 ()
Natrii hydroxydum ()
Caustic soda ()
P&D ID
PD061004
CAS
1310-73-2
Tags
available
inorganic
drug
Drug Status
approved
Drug indication
Pharmaceutic Aid (alkalizing agent)
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Because of its high-level alkalinity, sodium hydroxide in aqueous solution directly causes bond breakage in proteins (especially disulfide bridges). Hair and fingernails are found to be dissolved after 20 hours of direct contact with sodium hydroxide at pH values higher than 9.2 [L1975]. ; ; Sodium hydroxide has depilatory effects which have been described after accidental contact with solutions in the workplace. The breakage of bonds in proteins may lead to severe necrosis to the application site. The level of corrosion depends on the period of contact with the tissue, and on the concentration of sodium hydroxide [L1975].
ABSORPTION There are no quantitative data for the absorption of sodium hydroxide through the skin. Solutions which contain 50 % sodium hydroxide have been shown to be corrosive and lethal when applied dermally to mice [L1977].;
TOXICITY Human poisoning cases indicate that a dose of 10 grams orally is fatal [L1970]. Sodium hydroxide is toxic by oral ingestion [L1965].; ; Sodium hydroxide is corrosive to all tissues. Concentrated vapors lead to serious damage to the eyes and respiratory system. Oral ingestion of sodium hydroxide, which occurs frequently in children, causes severe tissue necrosis, with stricture formation of the esophagus, often resulting in death. Contact with the skin may result in contact dermatitis, hair loss, as well as necrosis due to severe irritation [L1972].; ; Increased incidence of esophageal carcinoma after severe intoxication with sodium hydroxide has been reported in man. In animal studies, long-term dermal contact with substances leading to pH changes in the skin causes the development of tumors, as a result of severe tissue irritation and reparative cell growth [L1977]. ; ; ; Mutagenic for mammalian somatic cells. May cause damage to the following organs: mucous membranes, upper respiratory tract, skin, eyes [MSDS]. Tumors are not to be expected if the effects of irritation are prevented [L1977]. ; ; To date, there are no relevant studies of the prenatal toxic effects of sodium hydroxide [L1977].;
Compound Sets
3
ChEMBL Drugs
CHEMBL2105794
DrugBank
DB11151
DrugBank Approved Drugs
DB11151
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
39.99
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.17
TPSA
30.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.26
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data