General
Preferred name
BROFAROMINE
Synonyms
CGP 11305A ()
Brofaromine Hydrochloride ()
Brofaromina ()
Consonar ()
P&D ID
PD060944
CAS
63638-91-5
63638-90-4
Tags
available
drug candidate
Drug indication
Anxiety disorder
Drug Status
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 ¦ÌM for MAO-A.
DESCRIPTION Brofaromine Hydrochloride is a reversible inhibitor of monoamine oxidase A(RIMA). It acts on norepinephrine, epinephrine, serotonin and dopamine. It was mainly used in the treatment of depression and anxiety. It was developed by Novartis and was in clinic phase 3, but now it was terminated. (BOC Sciences Bioactive Compounds)
Compound Sets
8
BOC Sciences Bioactive Compounds
brofaromine-hydrochloride-cas-63638-90-4-item-476065
ChEMBL Drugs
CHEMBL160347
DrugBank
DB13876
DrugMAP
DMTEQ0G
Mcule NIBR MoA Box Subset
MCULE-9636239767
MedChem Express Bioactive Compound Library
HY-13339
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
309.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
3.67
TPSA
34.4
Fraction CSP3
0.43
Chiral centers
0.0
Largest ring
6.0
QED
0.92
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
MAO-A Inhibitors
Target
Monoamine Oxidase
Pathway
Neuronal Signaling
Solubility
Soluble in DMSO, not in water
Source data