General
Preferred name
mivavotinib
Synonyms
TAK-659 hydrochloride ()
TAK-659 ()
Mivavotinib (monohydrochloride) ()
TAK-659 (monohydrochloride) ()
CB-659 (monohydrochloride) ()
CB-659 ()
TAK-659F ()
MIVAVOTINIB CITRATE ()
TAK-659 FREE BASE ()
Tak 659 ()
P&D ID
PD060787
CAS
1952251-28-3
1312691-33-0
Tags
available
drug candidate
Drug indication
Acute myeloid leukemia
Diffuse large B-cell lymphoma
Haematological malignancy
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TAK-659 an orally available inhibitor of spleen tyrosine kinase (SYK), which is in clinical development for solid tumour and lymphoma malignancies. We have drawn the structure as represented in .
DESCRIPTION Mivavotinib (TAK-659) an orally available inhibitor of spleen tyrosine kinase (SYK), which is in clinical development for solid tumour and lymphoma malignancies. We have drawn the structure as represented in . (GtoPdb)
PRICE 95
DESCRIPTION TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
13
AdooQ Bioactive Compound Library
A21885
ChEMBL Drugs
CHEMBL3979920
CHEMBL4594253
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB16849
DrugMAP
DMJH3U0
EU-OPENSCREEN Bioactive Compound Library
EOS101012
Guide to Pharmacology
9600
MedChem Express Bioactive Compound Library
HY-100867A
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
tak-659
TargetMol Bioactive Compound Library
T4209
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
344.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
1.55
TPSA
97.86
Fraction CSP3
0.47
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FLT3
SYK
JAK3
VEGFR2
ZAP70
"FLT3
FLT3,Syk
Pathway
Protein Tyrosine Kinase/RTK
Angiogenesis
Chromatin/Epigenetic
JAK/STAT Signaling
Stem Cells
Tyrosine Kinase/Adaptors
MOA
FLT inhibitor
JAK inhibitor
Syk inhibitor
Tyrosine Kinases inhibitor
VEGFR inhibitor
spleen associated tyrosine kinase inhibitor
Source data