General
Preferred name
mivavotinib
Synonyms
TAK-659 ()
TAK-659 hydrochloride ()
TAK-659 (monohydrochloride) ()
CB-659 (monohydrochloride) ()
Mivavotinib (monohydrochloride) ()
CB-659 ()
TAK-659F ()
Tak 659 ()
MIVAVOTINIB CITRATE ()
P&D ID
PD060787
CAS
1952251-28-3
1312691-33-0
Tags
available
drug candidate
Drug indication
Haematological malignancy
Diffuse large B-cell lymphoma
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TAK-659 an orally available inhibitor of spleen tyrosine kinase (SYK), which is in clinical development for solid tumour and lymphoma malignancies. We have drawn the structure as represented in .
DESCRIPTION Mivavotinib (TAK-659) an orally available inhibitor of spleen tyrosine kinase (SYK), which is in clinical development for solid tumour and lymphoma malignancies. We have drawn the structure as represented in . (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
13
AdooQ Bioactive Compound Library
A21885
ChEMBL Drugs
CHEMBL3979920
CHEMBL4594253
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB16849
DrugMAP
DMJH3U0
EU-OPENSCREEN Bioactive Compound Library
EOS101012
Guide to Pharmacology
9600
MedChem Express Bioactive Compound Library
HY-100867A
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
tak-659
TargetMol Bioactive Compound Library
T4209
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
344.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
1.55
TPSA
97.86
Fraction CSP3
0.47
Chiral centers
2.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
FLT3
SYK
JAK3
ZAP70
VEGFR2
"FLT3
FLT3,Syk
Pathway
Protein Tyrosine Kinase/RTK
Angiogenesis
Tyrosine Kinase/Adaptors
Chromatin/Epigenetic
JAK/STAT Signaling
Stem Cells
MOA
FLT inhibitor
JAK inhibitor
Syk inhibitor
Tyrosine Kinases inhibitor
VEGFR inhibitor
spleen associated tyrosine kinase inhibitor
Source data