General
Preferred name
POM2-C-HMBP
Synonyms
P&D ID
PD060735
Tags
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION POM2-C-HMBP is a synthetic, cell-permeable prodrug of the Vγ2Vδ2 effector T cell activating isoprenoid (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) . This comound shows improved internalization into target cells compared to HMBPP. Internalization was essential for engagement of BTN3A1, and the enhanced Vγ2Vδ2 effector T cell-mediated lysis of cancer cells was BTN3A1-dependent. Note that Vγ2Vδ2 effector T cells are also known as Vγ9Vδ2 cells. (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
1
Guide to Pharmacology
9616
External IDs
6
Properties
(calculated by RDKit )
Molecular Weight
408.19
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
10
Ring Count
0
Aromatic Ring Count
0
cLogP
3.64
TPSA
108.36
Fraction CSP3
0.78
Chiral centers
0.0
Largest ring
0.0
QED
0.25
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data