General
Preferred name
TAMARIXETIN
Synonyms
4'-O-methyl Quercetin ()
4'-O-methyl-Quercetin ()
P&D ID
PD060489
CAS
603-61-2
Tags
available
nuisance
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p (ClpP) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC50 of 49.73 ¦ÌM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis, and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways[1][2][3][4].
PRICE 221
DESCRIPTION Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy. (TargetMol Bioactive Compound Library)
Cell lines
8
Organisms
3
Compound Sets
5
Cayman Chemical Bioactives
22406
DrugMAP
DM0EP51
MedChem Express Bioactive Compound Library
HY-N1181
Nuisance compounds in cellular assays
TargetMol Bioactive Compound Library
TN1039
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
316.06
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.29
TPSA
120.36
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
1
Nonspecific/NOS
Flavonoid
Nuisance compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
inflammation
Akt
Apoptosis
Bacterial
ClpP
COX
Interleukin Related
JNK
p38 MAPK
Reactive Oxygen Species (ROS)
Reactive Oxygen Species
Pathway
Immunology/Inflammation
Metabolism
Anti-infection
Cell Cycle/DNA Damage
MAPK/ERK Pathway
Metabolic Enzyme/Protease
NF-κB
PI3K/Akt/mTOR
NF-¦ÊB
Source data