General
Preferred name
LPA2 Antagonist 1
Synonyms
P&D ID
PD060411
CAS
1017606-66-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION LPA2 antagonist 1 is a LPA2 antagonist with an IC50 of 17 nM.
PRICE 486
DESCRIPTION LPA2 antagonist 1 could block the Erk activation regulated by LPA(2) and proliferation of HCT-116 cells as a selective inhibitor of LPA2 protein. IC50: 17 nM (in vitro). It could also be used to assess the inhibiting effection in the process of anticancer (BOC Sciences Bioactive Compounds)
DESCRIPTION LPA2 antagonist 1 is a highly efficient LPA2 antagonist. (TargetMol Bioactive Compound Library)
Compound Sets
8
BOC Sciences Bioactive Compounds
lpa2-antagonist-1-cas-1017606-66-4-item-474316
Cayman Chemical Bioactives
22051
Drug Repurposing Hub
EUbOPEN Chemogenomics Library
EUB0000464
Mcule NIBR MoA Box Subset
MCULE-4878699392
MedChem Express Bioactive Compound Library
HY-18075
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T15786
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
499.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.11
TPSA
78.43
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
LPA2
LPAR2
LPL Receptor
Member status
member
MOA
Lysophosphatidate-2 receptor antagonist
lysophosphatidic acid receptor antagonist
Pathway
GPCR/G protein
Solubility
10 mM in DMSO
Recommended Cell Concentration
None
Source data