General
Preferred name
PD060299
Synonyms
5'-Guanosine-Diphosphate-Monothiophosphate ()
Guanosine 5'-[?-thio]triphosphate (lithium salt) ()
GTP??S tetralithium ()
P&D ID
PD060299
CAS
37589-80-3
94825-44-2
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
120
DESCRIPTION
GTP??S tetralithium (Guanosine 5'-[??-thio]triphosphate tetralithium) is a G-protein activator, a non-hydrolyzable GTP analog that protects proteins from proteolytic degradation.GTP??S tetralithium is involved in the detection of cells expressing recombinant receptors and endogenous receptors. GTP??S tetralithium is involved in the detection of GPCR signaling in cells expressing recombinant receptors as well as in cells and tissues expressing endogenous receptors, and can be assayed to measure agonist-induced desensitization of two human polymorphic ??2B-adrenoceptor variants.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
538.97
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
9
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
-1.98
TPSA
283.02
Fraction CSP3
0.5
Chiral centers
6.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
