General
Preferred name
Cyclo(his-pro)
Synonyms
Cyclo(his-pro) (TFA) ()
Cyclo(histidyl-proline) ()
Histidylproline diketopiperazine ()
Cyclo(histidyl-proline) (TFA) ()
Histidylproline diketopiperazine (TFA) ()
Cyclo(L-His-L-Pro) ()
P&D ID
PD060058
CAS
53109-32-3
936749-56-3
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone[1]. Cyclo(his-pro) TFA could inhibit NF-¦ÊB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses[2].
DESCRIPTION
Cyclo(his-pro) is an endogenous cyclic dipeptide that exerts oxidative damage protection by selectively activating the transcription factor Nrf2 signalling pathway.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
Cayman Chemical Bioactives
DrugBank
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
234.11
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
0.28
TPSA
81.58
Fraction CSP3
0.55
Chiral centers
2.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NF-¦ÊB
Endogenous Metabolite
Human Endogenous Metabolite
NF-κB
Pathway
NF-??
Metabolic Enzyme/Protease
Metabolism
Source data
