General
Preferred name
Radgocitabine
Synonyms
DFP-10917 ()
TAS-109 ()
CNDAC (hydrochloride) ()
CNDAC hydrochloride ()
Cndac ()
Deoxycytidine analogue tas-109 ()
Tas 109 ()
P&D ID
PD059037
CAS
134665-72-8
135598-68-4
Tags
available
drug candidate
Drug indication
Acute lymphoblastic leukaemia
Acute myeloid leukaemia
Colorectal cancer
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].
PRICE
90
DESCRIPTION
CNDAC hydrochloride, a nucleoside analog, is a metabolite of the sapacitabine.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
16
Organisms
1
Compound Sets
7
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
252.09
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.78
TPSA
134.39
Fraction CSP3
0.5
Chiral centers
4.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Nucleoside antimetabolite/analog
Drug Metabolite
Apoptosis
DNA/RNA Synthesis
Pathway
Cell Cycle/DNA Damage
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Metabolism
Metabolic Enzyme/Protease
Source data
