General
Preferred name
FUNAPIDE
Synonyms
TV 45070 ()
XEN402 ()
XEN-402 ()
XPF-002 ()
TV-45070 ()
XEN-401-S ()
Funapida ()
P&D ID
PD058988
CAS
1259933-16-8
Tags
available
drug candidate
Drug indication
Vasodilatation of extremities
Osteoarthritis
Pain
osteoarthritis, knee
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Funapide (TV 45070; XEN402) is an orally active inhibitor of voltage-gated sodium channels (VGSC) in the peripheral nervous system with IC50 values ??of 84 nM and 54 nM for Nav1.5 and Nav1.7, respectively. Funapide has analgesic effects[1][2].
PRICE
441
DESCRIPTION
Funapide (XEN-402) is a NaV1.7 channel inhibitor that is proposed for analgesic activity .
(GtoPdb)
DESCRIPTION
Funapide is a Nav1.7 and Nav1.8 voltage-gated sodium channel inhibitor under the development by Xenon Pharmaceuticals and Teva Pharmaceutical Industries. It is applicated for the treatment of a variety of chronic painconditions, including osteoarthritis, neuropathic pain, postherpetic, neuralgia, erythromelalgia and dental pain. In July 2014, Funapide has reached phase IIb clinical trials.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Funapide (TV 45070) is a potent Sodium Channel Nav1.7 inhibitor with potential anti-inflammatory activity for the treatment of erythema gangrenosum, musculoskeletal pain, knee osteoarthritis, and postherpetic nerves.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
429.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
3
cLogP
4.25
TPSA
61.14
Fraction CSP3
0.23
Chiral centers
1.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Nav1.7 channel
Sodium Channel
MOA
Sodium Channel blocker
VGSC Target
Nav1.2
Nav1.5
Nav1.6
Nav1.8
Pathway
Membrane Transporter/Ion Channel
Solubility
Soluble in DMSO
Source data
