General
Preferred name
NRX-1074
Synonyms
APIMOSTINEL ()
AGN-241660 ()
NRX1074 ()
P&D ID
PD058984
CAS
1421866-48-9
Tags
available
drug candidate
Drug indication
Major depressive disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist[1].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
503.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
1
cLogP
-1.36
TPSA
179.29
Fraction CSP3
0.6
Chiral centers
6.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
iGluR
Source data
