General
Preferred name
Osugacestat
Synonyms
BMS-906024 ()
AL101 ()
Bms 906024 ()
Al-101 ()
BM-0018 ()
BM0018 ()
P&D ID
PD058947
CAS
1401066-79-2
Tags
available
drug candidate
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
BMS-906024, a selective and orally active γ-secretase inhibitor, is a potent inhibitor of pan-Notch receptors with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch-1, -2, -3 and -4 receptors, respectively. It has broad-spectrum antineoplastic activity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
556.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
4.35
TPSA
104.86
Fraction CSP3
0.38
Chiral centers
3.0
Largest ring
7.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
gamma secretase inhibitor
Gamma-secretase inhibitor
Pathway
Neuronal Signaling
Stem Cell/Wnt
Target
Notch
γ-secretase
Solubility
Soluble in DMSO
Source data
