General
Preferred name
DEXMECAMYLAMINE
Synonyms
mecamylamine ()
TC-5214 ()
DEXMECAMYLAMINE HYDROCHLORIDE ()
NIH-11008 ()
Dexmecamilamina ()
Mecamylamine s-(+)-form hydrochloride ()
P&D ID
PD058936
CAS
107596-30-5
107538-05-6
Tags
available
drug candidate
drug
Drug indication
Palmar hyperhidrosis
Hypertension
Hyperhidrosis
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dexmecamylamine is a nicotinic channel modulator with antidepressant activity. It demonstrated positive effects in a number of animal models of depression and anxiety. It was active in the forced swim test in rats. It was also active in the behavioral despair test in mice. It was used in the treatment of major depression and was in clinical phase 3 trials, but now it was terminated. It was developed by Targacept. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
dexmecamylamine-cas-107538-05-6-item-475034
ChEMBL Drugs
CHEMBL2103881
CHEMBL2105753
DrugBank
DB11807
DrugMAP
DM8AM60
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2103881
NCATS Inxight Approved Drugs
6EE945D3OK
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
167.17
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
0
cLogP
2.42
TPSA
12.03
Fraction CSP3
1.0
Chiral centers
3.0
Largest ring
5.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Solubility
10 mM in DMSO
Source data