General
Preferred name
LITRONESIB
Synonyms
KF-89617 ()
LY2523355 ()
LY-2523355 ()
LY 2523355 ()
Kf89617 ()
KF 89617 ()
P&D ID
PD058904
CAS
910634-41-2
Tags
available
drug candidate
Drug indication
Acute myeloid leukaemia
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
litronesib, also known as LY2523355, is an inhibitor of the kinesin-related motor protein Eg5 with potential antineoplastic activity. Litronesib selectively inhibits the activity of Eg5, which may result in mitotic disruption, apoptosis and consequently cell death in tumor cells that are actively dividing. The ATP-dependent Eg5 kinesin-related motor protein (also known as KIF11 or kinesin spindle protein-5) is a plus-end directed kinesin motor protein that plays an essential role during mitosis, particularly in the regulation of spindle dynamics, including assembly and maintenance.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
511.23
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
2.42
TPSA
119.97
Fraction CSP3
0.61
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
KIF11
Kinesin
MOA
kinesin-like spindle protein inhibitor
Pathway
Cell Cycle/DNA Damage
cytoskeleton
Source data
