General
Preferred name
ACYLINE
Synonyms
Acyline (TFA) ()
MER-104 ()
P&D ID
PD058877
CAS
170157-13-8
Tags
available
drug candidate
Drug indication
Hypogonadism
Prostate cancer
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Acyline is a novel GnRH antagonist found in animal studies to be a potent suppressor of circulating gonadotropin and testosterone (T) levels.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
17
Molecular Weight
1531.74
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
14
Rotatable Bonds
40
Ring Count
7
Aromatic Ring Count
6
cLogP
3.4
TPSA
428.65
Fraction CSP3
0.42
Chiral centers
10.0
Largest ring
6.0
QED
0.02
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GNRH Receptor
Pathway
GPCR/G protein
Source data
